A Person of Interest is an individual who will be involved in a violent crime. The Machine, without indicating whether the individual is the victim or the perpetrator, supplies his or her Social Security number to Reese and Finch, who study their background and attempt to prevent the violent crime.
The following list includes all Persons of Interest who appeared in Season 5.
Used as part of a Samaritan plot to create a new superflu strain made of a combined human and bird flu. Died of the virus which the Machine found a cure to but Samaritan succeeded in its ultimate goal.
While believed to be the victim, Easton was in fact the enigmatic criminal mastermind known as "The Voice" and plotted to murder hitman Amir Siddiq to stop him from revealing to the cops his true identity. While Easton succeeded in his plot, he was killed minutes later by Carl Elias.
Alias of John Reese while hiding from Samaritan. While Reese, Shaw and Fusco saved the relevant number of the President of the United States, the Machine gave the irrelevant number of Reese's Riley alias to a second team made up of Logan Pierce, Harper Rose and Joey Durban. After determining that Riley was in fact Reese, Pierce's team provided backup for Reese's team from behind the scenes and extracted them after the Presidential assassination was thwarted.
Philip Hayes was the alias of head Samaritan operative John Greer. While it was suspected he was a victim who Finch was going to kill, Finch instead intended to launch the ICE-9 virus against Samaritan and Greer tried to murder Finch to stop him. Greer's attempt on Finch cost Greer's life, but the Machine was able to save Finch's life with the aid of Reese and Shaw.