Shaw's escape plan is executed, and she surfaces in a jail in Johannesburg, South Africa, originally set in motion one episode earlier, with the help of Root and The Machine. From there, Shaw is seen driving in a vehicle at night at a high rate of speed, presumably to an airport.
As a result of the events of the episode, Fusco asks for a new partner and distances himself from the team.
In a reversal of an earlier scene from “Brotherhood”, Elias gives Finch the novel Twelve O'Clock High.
When Dr. Mason realizes the nature of the flu her patients have, she contacts the Centers for Disease Control. The CDC, based in Atlanta, is the principal medical research body which handles emergencies that could become public health threats. The CDC was previously featured in “Honor Among Thieves”, when the Marburg virus was a potential threat.
To Samuel, Shaw says "I never was big on prison grub", which could imply that she spent time in prison at some point.
Bloopers and Continuity Errors
When Root tells Finch what to do to overpower the hospital administrator, he doesn't recognize that one of the words she gives him is a Dutch attack command for Bear. However, in “C.O.D.” Finch used the command to save Reese from Estonian gangsters.
The Patriot Act does not authorize quarantines. The authority to quarantine outbreaks is held by the CDC and other state and local public health agencies. However, the Patriot Act gives wide latitude of law enforcement against suspected terrorists. Reese was very familiar with this Act when he worked for the government. For some, it represents an abuse of power by the government which Vigilance was against. Reese's comment was tongue-in-cheek. In the end, the writer's reaffirm their beliefs about the Patriot Act when Jeff is told, "After 9/11, people were more than willing to allow the NSA to collect all of their personal data." This was only possible through The Patriot Act.
"Oops--think I skipped a step." (Shaw, upon knocking her nurse out and beginning her escape)
"Perhaps we should try altering one of the variables? For the sake of humanity. Or even just... us." (Root, to Finch)
"Sooner or later every ecosystem changes; it just requires the correct precursor." (Root, to Finch)
"Look man, if you're ever in New York, look me up." (Shaw, to Samuel, a prison inmate)
"After 7000 simulations, it's only logical that some of your old memories have been replaced by new ones. Now the two coexist, side-by-side... You're not sure of anything anymore are you?" (Lambert, to Shaw)
"Underneath all of that intellect, you're the darkest of all of us." (Elias, to Finch)